Hyodeoxycholic acid in Arisaema Cum Bile can alleviate pentylenetetrazol-induced epilepsy by activating p53/Nrf2/GPX4 to inhibit ferroptosis - PubMed
3 hours ago
- #traditional Chinese medicine
- #epilepsy
- #ferroptosis
- Hyodeoxycholic acid (HDCA) in Arisaema Cum Bile (ACB) alleviates pentylenetetrazol-induced epilepsy by inhibiting ferroptosis via the p53/Nrf2/GPX4 pathway.
- ACB, a traditional Chinese medicine, contains 37 chemical components, with 10 crossing the blood-brain barrier, including steroids and terpenoids.
- HDCA is identified as a key active component in ACB, reducing seizure frequency and severity in epileptic rats and improving cognitive function.
- In vitro studies show HDCA inhibits glutamate-induced ferroptosis in HT22 neurons, with effects mediated by Nrf2 activation.
- The study provides evidence for ACB and HDCA as potential treatments for epilepsy by targeting ferroptosis-related pathways.