m5C RNA methylation is dysregulated by oncogenic herpesviruses via c-Myc signaling to counteract host antiviral factors - PubMed
4 hours ago
- #Herpesviruses
- #RNA methylation
- #Host-pathogen interaction
- Herpesviruses, including KSHV and EBV, dysregulate m5C RNA methylation to evade host immune responses.
- KSHV lytic reactivation reduces m5C methyltransferases NSUN2/1 via suppression of c-Myc signaling.
- Downregulation of NSUN2/1 promotes KSHV lytic replication by destabilizing host antiviral mRNAs like TRIM25.
- TRIM25 depletion enhances KSHV replication, highlighting its role in antiviral defense.
- Similar m5C dysregulation mechanisms are observed in EBV infection, suggesting a common viral strategy.