Strain-level genetic heterogeneity and colonization dynamics drive microbiome therapeutic efficacy - PubMed
3 hours ago
- #FMT
- #NSCLC
- #microbiome
- Fecal microbiota transplantation (FMT) improves anti-PD-1 efficacy and progression-free survival in advanced PD-L1-negative NSCLC.
- Strain-level genetic heterogeneity within species influences therapeutic outcomes, with distinct strains having opposing effects.
- Engraftment of beneficial strains depends on species-intrinsic metabolic and immune evasion traits.
- Successful colonization by specific beneficial strain variants correlates with positive clinical outcomes.
- 38 priority species with robust engraftment potential and significant heterogeneity identified for precision therapeutics.
- The study establishes a strain-function-efficacy paradigm for microbiome drug development.