New approaches to uncover COPD pathobiology and develop therapies - PubMed
4 hours ago
- #COPD
- #Disease Mechanisms
- #Medical Research
- COPD was the third leading cause of global mortality in 2011 but receives limited research funding.
- The review covers COPD risk factors, including genetic, epigenetic, microbiome, and environmental interactions.
- Preclinical models and advanced technologies (single-cell transcriptomics, metabolomics, proteomics) are being used to study disease mechanisms.
- Patient cohorts and biomarkers for early COPD diagnosis are crucial for developing new therapies.
- COPD-iNET consortium facilitates collaboration among preclinical, translational, and clinical researchers.