STING causes replication stress and nascent DNA degradation via SAMHD1 - PubMed
4 hours ago
- #STING
- #SAMHD1
- #replication stress
- STING is an innate immune adaptor that can accumulate in the nucleus due to replication stress.
- Nuclear STING binds to nascent DNA and promotes replication stress in progeria and tumor cells.
- STING limits dNTP availability, causing replication fork slowing and stalling.
- STING facilitates MRE11-mediated nascent DNA degradation, hindering fork protection.
- SAMHD1 mediates STING's effects on dNTP depletion and nascent DNA degradation.
- Knockdown of SAMHD1 rescues replication fork speed and stability in STING-overexpressing cells.
- The STING-SAMHD1 axis drives replication stress and genome instability in progeria and tumor cells.
- A feedforward loop exists between innate immune signaling and impaired DNA replication.