Circulatory dietary and gut-derived metabolites predict early cognitive decline - PubMed
7 hours ago
- #Cognitive Decline
- #Gut-brain Axis
- #Metabolomics
- Metabolites from gut microbes may serve as early biomarkers for cognitive decline.
- Key protective metabolites like choline and indole propionic acid are lower in individuals with early cognitive impairment.
- Harmful metabolites such as indoxyl sulfate and kynurenic acid are elevated in early cognitive decline cases.
- A panel of six metabolites identified via machine learning classifies early cognitive decline with an AUC of 0.79.
- Gut bacterial changes linked to metabolite shifts highlight the gut-brain axis in cognitive health.