Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis - PubMed
3 hours ago
- #epigenetics
- #nanoparticles
- #osteoarthritis
- The BRD4/Nav1.7 axis drives inflammatory and metabolic dysfunction in osteoarthritis (OA), promoting mitochondrial impairment and catabolic activation in chondrocytes.
- A cartilage-targeting hydrogel nanoplatform is developed using chondrocyte membrane-coated nanoparticles to deliver a BRD4 PROTAC for selective protein degradation.
- This nanoplatform enables efficient intra-articular delivery, immune evasion, and targeted retention in cartilage, suppressing inflammation and restoring mitochondrial function.
- Treatment reduces cartilage degeneration and pain behaviors in mouse models of OA, establishing targeted BRD4 degradation as a disease-modifying strategy.