Porcine reproductive and respiratory syndrome virus exploits ESCRT-II subunit EAP20 for entry and replication - PubMed
a day ago
- #ESCRT
- #EAP20
- #PRRSV
- PRRSV exploits ESCRT-II subunit EAP20 for viral entry and replication.
- EAP20 facilitates PRRSV transport to early endosomes via clathrin-mediated endocytosis.
- EAP20 interacts with PRRSV nonstructural proteins (Nsp2, Nsp5, Nsp9) during replication.
- EAP20 anchors Nsp9 on perinuclear ER and aids in forming double-membrane vesicles.
- EAP20 is identified as a novel proviral factor and potential antiviral target.
- Findings provide insights for developing better PRRS control strategies.