Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation - PubMed
12 hours ago
- #Polyamine metabolism
- #Heart transplantation
- #CD8+ T cells
- Polyamines, especially spermidine, have cardiovascular protective, antitumor, and longevity-promoting properties.
- Polyamine metabolism is upregulated in T cells during acute rejection (AR) in both murine allografts and human AR samples.
- Inhibition of polyamine metabolism in T cells prevents AR and promotes long-term graft survival.
- Polyamine metabolism is crucial for the differentiation of cytotoxic CD8+ T cells.
- The regulatory effect is mediated by polyamine-dependent hypusination of eukaryotic initiation factor 5A (eIF5A).
- Targeting T cell polyamine metabolism could be a novel therapeutic strategy for treating AR in heart transplantation.