Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties - PubMed
a day ago
- #macrophage ontogeny
- #skull-bone marrow
- #microglia
- Microglia originate from yolk sac progenitors and persist with minimal input from adult hematopoiesis.
- Brain-engrafted monocyte-derived macrophages (MDMs) exhibit distinct transcriptional and epigenetic profiles compared to yolk-sac-derived microglia (YSMs).
- MDMs transiently express CD206, resembling a developmental stage of microglial precursors.
- Interleukin (IL)-34 and C-C chemokine receptor 2 (CCR2) modulate MDM engraftment and polarization.
- Both blood and skull marrow supply the niche for MDMs, resulting in origin-biased states.
- MDM engraftment enhances cuprizone-mediated demyelination in the central nervous system (CNS).