Extracellular vesicles modulate skin aging biomarkers in a 3D reconstructed full-thickness skin model - PubMed
4 hours ago
- #3D skin model
- #extracellular vesicles
- #skin regeneration
- Extracellular vesicles (EVs) are lipid-enveloped nanovesicles that facilitate intercellular communication.
- EVs from adipose-derived stem cells and umbilical cord-derived mesenchymal stem cells (UC-MSCs) were studied in 2D and 3D skin models.
- EVs promoted fibroblast and keratinocyte proliferation, increased epidermal thickness, and enhanced collagen IV and fibrillin 1 presence.
- Transcriptomic, miRNA-seq, and proteomic analyses revealed gene expression changes and potential drivers of skin regeneration.
- EVs modulate biomarkers linked to skin aging in 3D reconstructed skin models.
- The study suggests EVs could be used in next-generation regenerative skincare products.