Hepatic mitochondrial signaling as a systemic hub: inter-organ communication networks in aging and aging-related diseases - PubMed
4 hours ago
- #aging
- #inter-organ communication
- #mitochondrial signaling
- Hepatic mitochondrial signaling plays a central role in systemic aging and aging-related diseases.
- Three major classes of mitochondrial outputs are discussed: UPRmt-driven mitokines (e.g., FGF21, GDF15), metabolites from metabolic reprogramming, and mitochondrial danger signals (e.g., mtROS, oxidized mtDNA).
- These signals influence endocrine, metabolic, and immune pathways, affecting mitochondrial function, inflammation, and energy homeostasis across multiple organs.
- Aging shifts hepatic mitochondrial signaling from adaptive to maladaptive states, impacting bidirectional networks involving the gut, skeletal muscle, and immune system.
- Potential strategies for modulating hepatic mitochondrial outputs to restore systemic homeostasis in aging and aging-related diseases are outlined.