Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature - PubMed
3 hours ago
- #microfluidics
- #cancer-diagnosis
- #extracellular-vesicles
- Small extracellular vesicles (sEVs) provide a non-invasive method for early-stage multi-cancer detection.
- A 4-protein sEV biomarker panel (thrombospondin-1, nidogen-1, pentraxin-3, versican) was identified and validated across 22 cancer cell lines and 764 plasma/serum samples with high accuracy (AUC: 0.91-1.00).
- A multiplex sEV device combining nanoshearing microfluidics and SERS was developed for clinical application, enabling simultaneous detection of the 4-protein panel.
- The device successfully differentiated benign lung changes from early-stage lung cancer in a prospective cohort of 68 patients.
- The study highlights the scalability, simplicity, and cost-effectiveness of the multiplex microfluidic device for large-scale cancer screening.