SEC14L4 promotes the development of esophageal squamous cell cancer by inhibiting the ubiquitination and degradation of DDX3X via RNF39 - PubMed
3 hours ago
- #Esophageal cancer
- #Ubiquitination
- #Oncogene
- SEC14L4 is overexpressed in esophageal squamous cell cancer (ESCC) and correlates with advanced tumor stage and poor prognosis.
- SEC14L4 promotes ESCC cell proliferation, migration, and colony formation while inhibiting apoptosis.
- SEC14L4 interacts with DDX3X and inhibits its ubiquitination and degradation via RNF39.
- SEC14L4 activates the MAPK signaling pathway and inhibits ferroptosis, contributing to ESCC progression.
- Knockdown of SEC14L4 significantly reduces tumor growth in vivo, suggesting its potential as a therapeutic target.