Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model - PubMed
3 hours ago
- #Japanese encephalitis
- #neuroinflammation
- #spatial transcriptomics
- Spatial transcriptomics used to study Japanese encephalitis virus (JEV) progression in mice.
- Ly6c2+ monocytes identified as primary virus carriers and major source of IFN-γ in infected brains.
- Ackr1+ endothelial cell activation linked to blood-brain barrier disruption and immune cell chemotaxis.
- Crosstalk between Ly6c2+ monocytes and Ackr1+ endothelial cells drives inflammation and cell death.
- Study provides a framework for investigating other neurotropic viruses.