Context-Dependent Role of GDF15: GDF15+ Tumor-Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis - PubMed
7 hours ago
- #OSCC
- #GDF15
- #Macrophages
- GDF15 has a context-dependent role in tumor progression, with GDF15+ tumor-associated macrophages suppressing OSCC progression by enhancing phagocytosis.
- Single-cell RNA-sequencing revealed GDF15+ macrophages are enriched in ICB-sensitive OSCCs post-treatment, suggesting their role in tumor regression.
- GDF15 deficiency in macrophages accelerates tumor progression by reducing CD8+ T cell infiltration.
- Macrophage-intrinsic GDF15 enhances phagocytosis and antigen cross-presentation to CD8+ T cells via NF-κB signaling.
- Secreted GDF15 has a protumor role, which can be neutralized by GDF15 antibodies, highlighting its double-edged effect in cancer.
- The study provides insights into the dual roles of GDF15, advancing understanding for potential therapeutic strategies in OSCC.