Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in Adipocytes - PubMed
7 hours ago
- #adipocyte aging
- #cellular senescence
- #Pck1
- Pck1 deficiency in adipocytes accelerates mitochondrial dysfunction and cellular senescence.
- Loss of Pck1 impairs TCA cycle cataplerosis, leading to fumarate accumulation.
- Fumarate accumulation triggers mtDNA release and activates cGAS/STING signaling.
- Overexpression of Fh1 reduces fumarate levels and attenuates inflammaging.
- Targeting Pck1 may offer therapeutic strategies for age-related metabolic diseases.