Prospective head-to-head comparison of routine non-invasive scores for predicting severe cirrhosis-related morbidity in the general population - PubMed
4 hours ago
- #non-invasive tests
- #cirrhosis
- #risk prediction
- The study compares non-invasive risk scores for predicting severe cirrhosis-related morbidity in the general population.
- A systematic review identified 12 risk scores, including APRI and FIB-4, evaluated in the UK Biobank cohort.
- Severe cirrhosis-related morbidity had a 10-year cumulative incidence of 0.39% (1,498 events).
- Most novel risk scores outperformed APRI and FIB-4 in predicting cirrhosis-related morbidity.
- LiverRisk showed the highest discrimination at 5 and 10 years, followed closely by CORE.
- CORE achieved better enrichment of high-risk individuals compared to LiverRisk.
- A higher-threshold CORE-only strategy may outperform a sequential CORE-LiverRisk approach when referrals are limited.
- CORE and LiverRisk are the most discriminative tools for long-term cirrhosis-related morbidity prediction.