Helicobacter pylori induces the production of interleukin-37 to promote broad immunosuppression and enhance colonization - PubMed
7 days ago
- #immune suppression
- #interleukin-37
- #Helicobacter pylori
- Helicobacter pylori induces interleukin-37 (IL-37) production to promote immunosuppression and enhance colonization.
- IL-37 secretion is triggered by H. pylori via TLR2, TLR4, NOD1, and the cag pathogenicity island.
- IL-37 attenuates immune responses, including TLR-mediated activation and IL-8 production.
- Transgenic mice expressing human IL-37 showed increased H. pylori colonization and reduced inflammation.
- IL-37 impairs T and B cell activation, migration, and immune synapse formation.
- IL-37 inhibits proliferation of H. pylori-specific T cells from infected patients.
- Findings suggest IL-37 as a therapeutic target to combat H. pylori infection.