Plasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation - PubMed
4 hours ago
- #ECMO
- #Pediatrics
- #Brain Injury
- Study focuses on plasma biomarkers (GFAP, NfL, tau) for detecting acute brain injury (ABI) in children on ECMO.
- Elevated GFAP and NfL levels precede neuroimaging confirmation of ABI and correlate with unfavorable outcomes.
- 219 participants (224 ECMO courses) with median age 11 months; 54% male.
- GFAP and NfL levels increased significantly before ABI diagnosis (6.4% and 16.1% per 24 hours, respectively).
- Higher GFAP and NfL levels associated with unfavorable short-term and long-term outcomes.
- Tau levels showed no significant association with outcomes.
- GFAP and NfL may aid in real-time monitoring and guiding neuroprotective strategies in ECMO patients.