IFI35 suppresses the transcription of hepatitis B virus cccDNA minichromosome via promoting HNF4α proteasomal degradation - PubMed
8 hours ago
- #HNF4α degradation
- #HBV replication
- #IFI35
- IFI35 is identified as a novel host restriction factor that suppresses hepatitis B virus (HBV) transcription.
- IFI35 promotes the proteasomal degradation of hepatocyte nuclear factor 4α (HNF4α) by recruiting TRIM21 for K48-linked ubiquitination.
- The IFI35-TRIM21-HNF4α axis mediates cytokine-induced suppression of HBV cccDNA transcription and viral replication.
- Findings are validated in patient-derived primary human hepatocytes and a mouse model of HBV infection.
- This mechanism reveals a potential target for developing alternative anti-HBV drugs.