Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19 - PubMed
6 hours ago
- #immune dysregulation
- #long COVID
- #NK cells
- Long COVID (LTCS) is a post-viral condition with symptoms like fatigue and cognitive impairment, affecting 2%–8% after SARS-CoV-2 infection.
- LTCS patients show elevated anti-SARS-CoV-2 IgG but reduced systemic cytokines (e.g., IFN-γ, TNF-α) and depletion of CD56+CD16+ NK and NKT cells.
- Single-cell RNA-seq reveals NK cell loss, transcriptional reprogramming, and suppression of neurosensory pathways in LTCS, linking NK-cell dysfunction to enduring symptoms.