VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING - PubMed
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- VHL synthetic lethality screens identified CBF-β as a negative regulator of STING.
- Loss of CBF-β causes cell death in VHL-null ccRCC cell lines and impairs tumor growth in vivo.
- The synthetic lethality is independent of HIF activity but involves RUNX transcription factors.
- CBF-β loss upregulates type I interferon signaling and inhibits STING locus activity.
- Targeting CBF-β selectively induces tumor cell lethality and activates type I interferon signaling.