Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms - PubMed
4 hours ago
- #Sleep Disorders
- #Pathological Mechanisms
- #Neurodegenerative Diseases
- Neurodegenerative diseases (NDDs) like Alzheimer's and Parkinson's are a growing public health concern in aging populations.
- NDDs are marked by neuronal loss and protein aggregation, with sleep-wake disorders being a common non-motor symptom.
- Sleep disruption is both a consequence and a potential accelerator of neurodegeneration.
- Key mechanisms linking sleep disorders and NDDs include impaired protein homeostasis, glymphatic dysfunction, and neuroinflammation.
- Current interventions for sleep disorders in NDDs include both pharmacological and non-pharmacological approaches.
- Addressing sleep disorders may offer both symptomatic relief and disease-modifying benefits for NDDs.