Hemocyte-secreted papilin bearing mucin-type O-glycans regulates peripodial stalk formation via epidermal JAK/STAT signaling in Drosophila - PubMed
7 hours ago
- #developmental biology
- #glycobiology
- #JAK/STAT signaling
- Hemocyte-secreted papilin (Ppn) with mucin-type O-glycans regulates peripodial stalk formation in Drosophila.
- T antigen-modified Ppn suppresses JAK/STAT signaling in the epidermis around Keilin's organ, essential for proper leg morphogenesis.
- Disrupted mucin-type O-glycosylation impairs Ppn secretion, leading to mislocalized leg discs and developmental defects.
- The study highlights the role of immune-like cells (hemocytes) in organogenesis via extracellular matrix (ECM) signaling.