The critical role of discoidin domain receptors in the regulation of anti-tumor immune responses - PubMed
5 hours ago
- #immunotherapy
- #DDRs
- #tumor immunity
- Discoidin domain receptors (DDRs) are non-integrin collagen receptors involved in tumorigenesis, growth, and metastasis.
- DDRs contribute to immune checkpoint inhibitor (ICI) resistance by altering the tumor microenvironment.
- DDR1 mediates collagen fiber rearrangement, increases IL-18 secretion, and promotes neutrophil extracellular traps (NETs).
- DDR2 recruits myeloid-derived suppressor cells (MDSCs) and induces M2 macrophage polarization, fostering immunosuppression.
- Targeting DDRs and collagen can restore anti-tumor immunity, but clinical validation is needed.
- DDRs are promising therapeutic targets to enhance ICI efficacy in cancer treatment.