Cardiovascular risk equations in type 1 diabetes: from generic models to personalized prediction - PubMed
3 hours ago
- #Type 1 diabetes
- #Cardiovascular risk
- #Precision medicine
- Cardiovascular disease (CVD) is the leading cause of premature mortality in type 1 diabetes (T1D).
- Current prevention guidelines and risk stratification tools for T1D are often extrapolated from type 2 diabetes or general populations, missing unique T1D-specific factors.
- Generic risk calculators like SCORE2 and ACC/AHA pooled cohort equations have short-term prediction horizons and lack validation in T1D cohorts.
- T1D-specific risk equations (e.g., Steno-Risk, LIFE-T1D) incorporate disease-specific variables (e.g., diabetes duration, albuminuria) and show superior discriminatory performance.
- Despite improved calibration, T1D-specific tools still classify many with subclinical atherosclerosis as 'moderate risk,' complicating therapeutic decisions.
- Precision medicine in T1D requires integrating validated risk calculators, subclinical atherosclerosis screening (e.g., carotid ultrasound, CAC scoring), and novel biomarkers.