Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions - PubMed
9 hours ago
- #gut-muscle axis
- #microbiome
- #sarcopenia
- Age-related sarcopenia involves loss of skeletal muscle mass, strength, and function, increasing risks of falls, fractures, and mortality.
- Age-related changes in the gut microbiome include reduced diversity, altered metabolite production, and compromised intestinal barrier function.
- Changes in microbial metabolites and toxins (e.g., decreased short-chain fatty acids, increased lipopolysaccharides, bile acid imbalance) may contribute to sarcopenia by impairing muscle protein turnover.
- Lifestyle approaches (exercise, diet) and microbiome-targeted interventions (pre-, pro-, post-biotics) are proposed to combat sarcopenia, but clinical evidence is limited.
- Emerging strategies like Urolithin A and fecal microbiome transplants (FMT) show potential for treating age-related sarcopenia.