Hepatitis B Vaccine Response in Children of Vaccinated Versus Unvaccinated Mothers: A Retrospective Cohort Study - PubMed
12 hours ago
- #Vaccination
- #Hepatitis B
- #Antibody Response
- Universal infant hepatitis B (HBV) vaccination is highly effective in preventing infection.
- Study compares vaccine-induced antibody responses in children of vaccinated vs. unvaccinated mothers.
- Children born to mothers vaccinated prior to pregnancy were more likely to achieve very high antibody levels (≥ 1000 mIU/mL).
- Seroprotection rates (≥ 10 mIU/mL) were high (89.3%) and did not differ significantly between groups.
- Mean anti-HBs titers were highest in offspring of vaccinated mothers.
- Older maternal age and lower hemoglobin levels impaired the response, but HBIG did not.
- Findings suggest a possible intergenerational enhancement of vaccine responsiveness.