The role of TDP-43 fragments in regular cellular functions and homeostatic failure - PubMed
3 hours ago
- #proteinopathies
- #TDP-43
- #ALS
- TDP-43 is an RNA/DNA-binding protein that regulates gene expression, RNA transcription, splicing, stability, and transport under normal conditions.
- In over 95% of ALS cases, TDP-43 mislocalizes to the cytoplasm, forming inclusions with misfolded, ubiquitinated, phosphorylated, and fragmented species.
- The role of TDP-43 fragments in cytotoxicity and neurodegeneration remains debated.
- TDP-43 fragments may have homeostatic functions in viral infections and myelination control.
- Understanding TDP-43 fragments could lead to new treatments for ALS and other TDP-43 proteinopathies.