IFI44 Promotes Clear Cell Renal Cell Carcinoma Progression via PRDX1 and Predicts Poor Prognosis - PubMed
4 days ago
- #PRDX1
- #IFI44
- #ccRCC
- IFI44 is identified as a key gene in clear cell renal cell carcinoma (ccRCC) progression.
- High IFI44 levels correlate with advanced tumor stages and poorer survival in ccRCC patients.
- IFI44 participates in viral response, RNA splicing, and mRNA processing pathways.
- IFI44 promotes an immunosuppressive tumor microenvironment by altering immune cell infiltration.
- Knockdown of IFI44 reduces cell proliferation, migration, invasion, and triggers apoptosis in ccRCC cells.
- PRDX1 interacts with IFI44 and can rescue the oncogenic effects of IFI44 knockdown.
- IFI44 is suggested as a potential biomarker and therapeutic target for ccRCC.