Effects of tirzepatide, a dual GIP and GLP-1 receptor agonist, on blood pressure, cardiac function, and sympathetic nervous system in stroke-prone spontaneously hypertensive rats - PubMed
2 hours ago
- #Blood Pressure
- #Cardiac Function
- #Tirzepatide
- Tirzepatide, a dual GIP and GLP-1 receptor agonist, increased blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.
- Treatment led to adverse cardiac effects including left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function.
- Sympathetic nervous system activation was observed, indicated by higher plasma norepinephrine and ΔFosB expression in brain regions linked to sympathetic outflow.
- The findings contrast with clinical observations in obese and diabetic patients, suggesting context-dependent cardiovascular actions of tirzepatide.