Smart oral delivery of curcumin nanoparticulate systems for targeted colorectal cancer therapy: strategies, applications, and future perspectives - PubMed
3 hours ago
- #nanomedicine
- #colorectal cancer
- #drug delivery
- Colorectal cancer (CRC) is ideal for oral nanomedicine due to its anatomical location.
- Curcumin (CUR) has potential for CRC therapy but suffers from poor solubility, rapid metabolism, and low bioavailability.
- Smart nanoparticulate systems exploit CRC hallmarks like pH gradients, enzymes, redox imbalance, and receptor upregulation.
- These systems use microenvironment sensing and signal-responsive activation for precision drug release.
- The review covers CUR's pharmacological profile, smart oral nanoformulations, and combined targeting strategies.
- Future directions include patient stratification, biomimetic designs, and clinical translation.