Resveratrol combats Salmonella infection via liberating vacuole-enclosed bacteria for enhanced autophagic clearance and blocking HMGA2-mediated G2/M arrest - PubMed
a day ago
- #Salmonella
- #Host-directed therapy
- #Resveratrol
- Resveratrol clears intracellular Salmonella typhimurium by disrupting Salmonella-containing vacuoles (SCV) via ERK1/2 inhibition.
- The liberated bacteria are then cleared through enhanced autophagy.
- Resveratrol reverses pathogen-induced G2/M cell cycle arrest by targeting High Mobility Group AT-Hook 2 (HMGA2).
- A resveratrol derivative, RV15, shows enhanced potency and a distinct target profile.
- The study highlights the potential of host-directed therapies (HDTs) to combat antibiotic-resistant pathogens.