Single-cell transcriptome-wide Mendelian randomization during CD4+ T cell activation reveals immune-mediated mechanisms and drug targets for neuropsychiatric disorders - PubMed
3 hours ago
- #Mendelian randomization
- #neuropsychiatric disorders
- #immune mechanisms
- Combined single-cell transcriptomics of CD4+ T cell activation with Mendelian randomization to identify causal genes for Alzheimer's disease and major depressive disorder.
- Identified 73 causal genes for Alzheimer's disease and 156 for major depressive disorder, with over 90% validation in independent datasets.
- Found 29 genes specific to CD4+ T cells and 34 genes with temporal causal patterns, showing higher genetic evidence links for the disorders.
- Prioritized 21 genes, including RAC1 and PARP1, as potential drug repurposing targets for neuropsychiatric disorders.