Potent efficacy of an NA-targeting antibody against a broad spectrum of H5N1 influenza viruses - PubMed
4 hours ago
- #monoclonal antibody
- #H5N1
- #influenza vaccine
- FNI9, a pan-influenza NA-inhibiting monoclonal antibody, shows potent in vitro activity against a broad range of H5N1 influenza viruses.
- FNI9 provides strong prophylactic protection in mice against lethal challenges from H5N1 clade 1 and 2.3.4.4b.
- Cryo-EM and molecular dynamics reveal FNI9 binds to 7 highly conserved H5N1 NA residues, indicating broad protection potential.
- In silico analysis predicts low escapability and high fitness costs for viral mutations that evade FNI9 binding.
- The findings highlight the importance of NA in future influenza vaccine design.