A translational systems medicine approach to devising nanotherapeutics for targeted intervention of MASLD - PubMed
3 hours ago
- #Nanotherapeutics
- #Systems Medicine
- #MASLD
- MASLD and MASH are significant clinical challenges with limited treatment options.
- A new therapeutic strategy was developed using a translational systems medicine approach.
- ERN1 (IRE1α) was identified as a key regulatory node in MASLD progression.
- A hepatoselective ROS-scavenging LNP encapsulating KIRA6 was engineered.
- Preclinical models showed reduced hepatic lipid accumulation, inflammation, and fibrosis.
- The study offers a framework for pathophysiology-informed treatment strategies.