Lipid-Engineered Small-Sized Metal-Organic Frameworks for Targeted Delivery of Anlotinib in Lung Cancer Treatment - PubMed
4 hours ago
- #lung-cancer
- #targeted-drug-delivery
- #nanomedicine
- Lipid-engineered small-sized MIL-101(Fe) MOF (Anlo@MOF-Lipo or AML) designed for targeted anlotinib delivery in lung cancer.
- Biomimetic liposome shell enhances biocompatibility; MIL-101(Fe) core enables pH-responsive Fe3+ release for Fenton-like reactions and ROS generation.
- Anlotinib encapsulated in MOF pores ensures sustained intratumoral release, inhibiting tumor growth.
- AML showed superior cellular uptake, cytotoxicity in vitro, and greater tumor reduction in murine models vs. free anlotinib.
- Dual therapy: targeted chemotherapy + oxidative stress induction highlights AML's potential for lung cancer treatment.