COL1A1-induced LOXL2 promotes ovarian cancer metastasis via a feedback loop upon inhibiting EGFR lysosomal degradation - PubMed
a day ago
- #ovarian cancer
- #metastasis
- #LOXL2
- COL1A1-induced LOXL2 promotes ovarian cancer metastasis via a feedback loop involving EGFR-MEK-ERK-SP1.
- LOXL2 is overexpressed in ovarian cancer tissues and ascites, serving as an independent prognostic risk factor.
- COL1A1 activates the EGFR-MEK-ERK pathway, leading to SP1 nuclear translocation and increased LOXL2 transcription.
- LOXL2 interacts with EGFR, preventing its lysosomal degradation and enhancing its stability.
- The feedback loop involving EGFR-MEK-ERK-SP1-LOXL2 offers potential therapeutic targets for inhibiting ovarian cancer metastasis.
- The study was supported by the National Natural Science Foundation of China.