Semaglutide Plus Low-Dose Metformin Combination Therapy for the Treatment of Obesity and Prediabetes in a Woman with Partial Deletion of the X Chromosome Long Arm - PubMed
7 hours ago
- #Obesity treatment
- #Semaglutide
- #X chromosome deletion
- First case report on using once-weekly subcutaneous semaglutide plus low-dose metformin to treat obesity and prediabetes in a woman with partial Xq deletion.
- Patient, a 65-year-old woman, achieved significant weight loss (13.8 kg, 20.95% total body weight) and improved metabolic markers (HbA1c reduction, normalized insulin sensitivity indices) over 8 months.
- Body composition improved with fat mass loss (-10.3 kg), increased percent fat-free mass, and normalization of BMI from obesity to overweight (31.8 to 25.1 kg/m²).
- Abdominal ultrasound showed resolution of mild-to-moderate hepatic steatosis at 6 months; therapy was well-tolerated.
- Highlights need for further studies on semaglutide's safety and efficacy in patients with X chromosome abnormalities and metabolic disorders.