Immunophenotypic Stratification of Primary Sjögren's Syndrome Reveals Distinct Lymphocyte Profiles and Clinical Manifestations - PubMed
7 hours ago
- #autoimmune
- #Sjögren's
- #lymphocyte
- Primary Sjögren's syndrome (pSS) is a heterogeneous autoimmune disorder with diverse clinical manifestations.
- The study analyzed 133 Chinese pSS patients and 241 healthy controls using flow cytometry to profile 11 lymphocyte subsets.
- Three distinct immunophenotypic subgroups were identified: Cluster 1 (higher CD8+ T cells, more hematologic/serological abnormalities), Cluster 2 (higher NK/B cells, greater pulmonary/hepatic involvement), and Cluster 3 (lymphocyte distributions closest to healthy controls, more constitutional symptoms).
- Lymphocyte profiling may help stratify pSS patients into clinically distinct subgroups, aiding personalized management.
- The study highlights the potential of immunophenotyping in understanding pSS pathobiology and improving patient stratification.