Microglial PRMT2IP alleviates ischemia-induced brain injury - PubMed
3 hours ago
- #Ischemic Stroke
- #Neuroinflammation
- #Microglia
- PRMT2IP modulates microglial activation in ischemic stroke and reduces brain injury.
- Mendelian randomization shows downregulation of PRMT2IP increases ischemic stroke risk.
- PRMT2IP overexpression protects against cerebral ischemia, while knockout worsens outcomes.
- PRMT2IP interacts with PRMT2 and inhibits NF-κB signaling, reducing IL-6 and TNFα.
- Up-regulation of PRMT2IP may be a therapeutic strategy for post-stroke neuroinflammation.