Endogenous α-Klotho is a common target in atherosclerosis and calcific aortic valve disease - PubMed
8 hours ago
- #Aortic Valve Disease
- #Atherosclerosis
- #α-Klotho
- Endogenous α-Klotho expression is significantly reduced in atherosclerotic vessels and stenotic aortic valves, with variation across vascular territories.
- Tissue and circulating α-Klotho levels are inversely associated with inflammatory and calcification markers, suggesting a protective role.
- Pro-inflammatory stimuli downregulate α-Klotho in vascular smooth muscle cells and valve interstitial cells, while α-Klotho silencing amplifies inflammation and promotes calcification.
- Recombinant α-Klotho supplementation attenuates inflammation and inhibits osteogenic differentiation in vitro, indicating therapeutic potential.
- α-Klotho is implicated as a common inflammatory mediator in both atherosclerosis and calcific aortic valve disease.