Maternal granulocyte colony-stimulating factor alters synaptic maturation and social behaviors in offspring - PubMed
3 hours ago
- #maternal immune activation
- #autism spectrum disorder
- #neurodevelopmental disorders
- Maternal granulocyte colony-stimulating factor (G-CSF) alters synaptic maturation and social behaviors in offspring.
- Maternal immune activation (MIA) increases G-CSF levels in maternal plasma and embryonic tissue.
- Prenatal exposure to G-CSF leads to increased dendritic spine density and immature spines in the medial prefrontal cortex in male offspring.
- Both male and female offspring exhibit altered social preference after prenatal G-CSF exposure.
- RNA-seq analysis shows altered pathways related to synapse organization, translation, and mitochondrial function in the prefrontal cortex.
- G-CSF attenuates synapse maturation and enhances microglial phagocytic activity in vitro.
- G-CSF may contribute to neurodevelopmental disorders like autism spectrum disorder (ASD) through disrupted synapse maturation and microglial function.