Effects of gestational exposure to individual and mixed PFASs on maternal liver function: evidence from the Wuxi Birth Cohort, animal studies, and toxicogenomic analyses - PubMed
7 hours ago
- #PFAS
- #Pregnancy
- #Liver Function
- Study investigates effects of gestational PFAS exposure on maternal liver function using data from the Wuxi Birth Cohort, animal studies, and toxicogenomic analyses.
- PFASs, persistent environmental contaminants, show potential hepatotoxicity, with impacts during pregnancy being poorly characterized.
- 601 pregnant women were studied, measuring 23 PFASs and 11 liver function markers in serum.
- Associations between PFASs and liver function markers were evaluated using GLM, GAM, WQS, and BKMR models.
- Twelve PFASs had detection rates above 90%, with PFPeA being the most predominant compound.
- PFOA, PFNA, PFDA, and PFUdA were significantly associated with elevated ALT, AST, GGT, and ALP levels.
- PFAS mixtures showed positive associations with liver function markers, particularly ALT, AST, and ALP.
- Animal studies with PFDA and PFNA exposure in pregnant rats confirmed altered liver function markers.
- Transcriptomic analyses revealed disruptions in hepatic metabolic pathways like unsaturated fatty acid biosynthesis and PPAR/AMPK signaling.
- Findings suggest PFAS exposure during pregnancy may have implications for maternal liver health.