The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta-Analysis - PubMed
a day ago
- #muscle health
- #SGLT2 inhibitors
- #older adults
- SGLT2 inhibitors significantly reduce body weight and fat mass in older adults with type 2 diabetes.
- A small reduction in muscle mass was observed, but it was substantially smaller than fat loss.
- Subgroup analysis confirmed fat mass reduction with dapagliflozin/ipragliflozin and empagliflozin.
- Weight reduction occurs primarily through favorable metabolic changes, with modest muscle mass decline.
- Careful monitoring in older adults is warranted due to slight muscle mass changes and study heterogeneity.
- Further studies in diverse populations are needed to confirm findings.