Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone - PubMed
19 hours ago
- #Brain Invasion
- #Microglia
- #Glioblastoma
- Microglia-glioblastoma interactions are studied in a mouse model using three-photon imaging.
- Microglia surveillance increases in sparsely infiltrated areas but decreases with higher glioblastoma density.
- Directional migration toward glioblastoma cells is limited to specific microglial subsets within a spatial range.
- CX3CR1 deficiency boosts microglial reactivity and reduces glioblastoma cell migration.
- Microglia depletion with CSF1R inhibitor PLX5622 decreases glioblastoma migration and limits tumor microtube plasticity.
- Microglia modulate glioblastoma dissemination at the far infiltration zone in a stage-dependent manner.