Ligilactobacillus salivarius Li01 enhances gut microbiota-derived indole-3-propionic acid to alleviate 5-fluorouracil-induced diarrhea in mice - PubMed
5 hours ago
- #probiotics
- #chemotherapy side effects
- #gut microbiota
- Ligilactobacillus salivarius Li01 (Li01) alleviates 5-fluorouracil (5-FU)-induced diarrhea in mice.
- Li01 mitigates inflammation, reduces oxidative stress, and restores intestinal barrier function.
- The Th17 signaling pathway is significantly suppressed by Li01 administration.
- Gut microbiota depletion by antibiotics eliminates the protective effects of Li01.
- Li01 increases gut microbiota-derived indole-3-propionic acid (IPA), which activates the pregnane X receptor (PXR) to protect against diarrhea.
- IPA levels correlate with the abundance of Lactobacillus reuteri and Lactobacillus johnsonii, which form a mutualistic relationship with Li01.
- Li01 shows potential as a probiotic for managing 5-FU-induced diarrhea and microbiota dysbiosis.