Chondrocytes reprogram chromatin in hypoxic microenvironments to activate CADM1-AS1/HDAC1 complex-mediated anti-inflammation signals - PubMed
3 hours ago
- #epigenetics
- #chondrocytes
- #osteoarthritis
- Chondrocytes in hypoxic conditions reprogram chromatin and alter histone acetylation.
- The long non-coding RNA CADM1-AS1 regulates cartilage homeostasis by recruiting HDAC complexes.
- CADM1-AS1 suppresses NOS2 transcriptional activation, affecting chondrocyte amino acid metabolism.
- Conditional knockout of CADM1-AS1 accelerates osteoarthritis development in male mice.
- A hybrid exosome delivery system modulating CADM1-AS1 expression reduces cartilage damage.
- CADM1-AS1-mediated epigenetic regulation is a potential therapeutic target for osteoarthritis.