Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture - PubMed
4 days ago
- #lysosome
- #cell death
- #ferroptosis
- Ferroptosis is a lipid peroxide-dependent cell death mechanism relevant in degenerative conditions and cancer therapy.
- Ferroptosis exhibits collective properties involving propagation between cells, with mechanisms less understood compared to cell-autonomous execution.
- Different ferroptosis induction modes (GPX4 inhibition vs. glutathione depletion) affect collective death responses differently.
- Lysosome rupture is significant during propagative ferroptosis, and glutathione depletion can convert GPX4 inhibition into a collective response.
- Single-cell ferroptosis involves heterogeneous death profiles, with necrosis and apoptosis occurring simultaneously in cell populations.
- Lysosomes are critical to ferroptosis execution, influencing propagation and death profiles.